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The International Consortium to Classify Ageing-Related Pathologies (ICCARP) aims to prepare healthcare systems to meet the needs of ageing populations worldwide. As societies age, age-related diseases present growing challenges to healthcare systems, workforce productivity, and economic stability. To meet these challenges, ICCARP is developing a comprehensive classification and staging system for age-related pathologies, based on expert consensus and the latest scientific evidence. This system will enhance understanding and inform future interventions to slow, prevent, or reverse disease progression, supporting health and quality of life in older age.
Funded by Longevity Impetus Grants, ICCARP comprises sixteen specialist working groups with over 300 experts, collaborating to develop classifications for submission to the UN’s World Health Organization.
Consortium Founders: Barry L Bentley, Stuart RG Calimport
Consortium Coordinators: Emma Short, Robert Huckstepp, Gary Christopher
Publications
The ICCARP Consensus Statements
Short E, ... Bentley BL (2024) Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement. GeroScience. doi:10.1101/2024.09.02.24312951
Short E, ... Bentley BL (2025) International Consortium to Classify Ageing-Related Pathologies (ICCARP) Senescence Definitions: Achieving International Consensus. GeroScience. doi:10.1007/s11357-025-01509-9 (pdf)
The ICCARP (2024) Infographic - Defining Senescence. doi:10.6084/m9.figshare.28024571 (jpg)
Short E, ... Bentley BL (2024) Adrenal cortex senescence: an ageing-related pathology? (Pre-print). doi:10.6084/m9.figshare.27841362
Short E, ... Bentley BL (2024) Pineal gland senescence: an emerging ageing-related pathology? (Pre-print). doi:10.5281/zenodo.13868748
Consortium Proposal
Abstract
Globally, citizens exist for sustained periods in states of aging-related disease and multimorbidity. Given the urgent and unmet clinical, health care, workforce, and economic needs of aging populations, we need interventions and programs that regenerate tissues and organs and prevent and reverse aging-related damage, disease, and frailty. In response to these challenges, the World Health Organization (WHO) has called for a comprehensive public-health response within an international legal framework based on human rights law. Yet for a clinical trial to be conducted, a disease to be diagnosed, intervention prescribed, and treatment administered, a corresponding disease classification code is needed, adopted nationally from the WHO International Classification of Diseases (ICD). Such classifications and staging are fundamental for health care governance among governments and intergovernmental bodies. We describe a systematic and comprehensive approach to the classification and staging of organismal senescence and aging-related diseases at the organ and tissue levels in order to guide policy and practice and enable appropriate interventions and clinical guidance, systems, resources, and infrastructure.
Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G (2019) To help aging populations, classify organismal senescence. Science, 366(6465), pp. 576-578. doi:10.1126/science.aay7319 (pdf)
Eid. (2020) The inherent challenges of classifying senescence—Response. Science, 368(6491), pp. 595-596. doi:10.1126/science.abb4073 (pdf)
Aging classified as a cause of disease in ICD-11
Calimport SRG & Bentley BL (2019) Aging classified as a cause of disease in ICD-11. Rejuvenation Research, 22(4), pp. 281. doi:10.1089/rej.2019.2242 (pdf)
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